Monograph Details
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Musculoskeletal Disorders
> Arthritis/rheumatic disorders
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ANSAID |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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NSAID (phenylalkanoic acid deriv.). |
| Generic Name |
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Flurbiprofen 50mg, 100mg; tabs. |
| Indications |
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Rheumatoid arthritis. Osteoarthritis. |
| Children |
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Not recommended. |
| Adults |
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200–300mg/day in 2–4 divided doses; max single dose 100mg. Reduce dosage for renal impairment. |
| Contraindications |
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Aspirin allergy. Late pregnancy. Coronary artery bypass graft surgery. |
| Precautions |
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Advanced renal disease: not recommended. Upper GI disease. Renal or hepatic dysfunction. Hypertension. Cardiac failure. Bleeding disorders. Hemoglobin <10g/dL. Monitor blood, hepatic, renal, and ocular function in chronic use. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Reduced diuresis and renal failure with diuretics. Attenuated antihypertensive effect of β-blockers (except atenolol). Monitor oral anticoagulants. Avoid aspirin. May potentiate lithium (monitor for toxicity), methotrexate. |
| Adverse Reactions |
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Peptic ulcers, GI bleeding, renal failure, anemia, ocular changes, edema, elevated SGOT or SGPT level, hepatitis, nausea, vomiting, diarrhea, constipation, headache, CNS stimulation or depression, rhinitis, rash (discontinue if occurs), dizziness, tinnitus, UTI-like signs and symptoms. See literature re: risk of cardiovascular events. |
| How Supplied |
Tabs 50mg—100
100mg—100, 2000 |
| Additional Resources |
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• Related Prescribing Note |
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