Monograph Details
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Infections & Infestations
> Viral infections
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VALTREX |
| Manufacturer |
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GlaxoSmithKline Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Nucleoside analogue. |
| Generic Name |
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Valacyclovir (as HCl) (prodrug of acyclovir) 500mg, 1g+; caplets; +scored. |
| Indications |
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Treatment of herpes zoster or herpes labialis. Treatment or suppression of genital herpes in immunocompetent patients. To reduce risk of heterosexual transmission of genital herpes from immunocompetent patients to susceptible partner. Suppression of recurrent genital herpes in HIV-infected patients. |
| Children |
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Not recommended. |
| Adults |
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Begin at onset of signs/symptoms (within 48–72 hours for herpes zoster or initial episode of genital herpes; within 24 hours for recurrent genital herpes). Coincide a dose for after hemodialysis. Herpes zoster: 1g every 8 hours; CrCl 30–49mL/min: 1g every 12 hours; CrCl 10–29mL/min: 1g every 24 hours; CrCl <10mL/min: 500mg every 24 hours; all for 7 days. Initial episode of genital herpes: 1g every 12 hours; CrCl 10–29mL/min: 1g every 24 hours; CrCl <10mL/min: 500mg every 24 hours; all for 10 days. Treatment of recurrent genital herpes: 500mg every 12 hours; CrCl ≤29mL/min: 500mg every 24 hours; both for 3 days. Suppression of recurrent genital herpes if immunocompetent (>9 episodes/year; reevaluate annually): 1g every 24 hours; CrCl ≤29mL/min: 500mg every 24 hours; (≤9 episodes/year): 500mg every 24 hours; CrCl ≤29mL/min: 500mg every 48 hours; Reduction of genital herpes transmission risk (≤9 episodes/year): 500mg every 24 hours for source partner (and use safer sex practices); CrCl ≤29mL/min: 500mg every 48 hours; Suppression of recurrent genital herpes if HIV-infected: 500mg every 12 hours; CrCl ≤29mL/min: 500mg every 24 hours. Herpes labialis (treat for 1 day): 2g every 12 hours; CrCl 30–49mL/min: 1g every 12 hours; CrCl 10–29mL/min: 500mg every 12 hours; CrCl <10mL/min: 500mg once. |
| Precautions |
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Renal impairment. Maintain adequate hydration. Elderly. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Renal or CNS toxicity with nephrotoxic drugs. |
| Adverse Reactions |
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GI upset, headache, dizziness, fatigue, rash, lab abnormalities (CBC, AST, serum creatinine). Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (in advanced HIV or transplant recipients on 8g/day). |
| How Supplied |
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Caplets—30, 90 |
| Additional Resources |
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• Related Prescribing Note |
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