Monograph Details
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Infections & Infestations
> Viral infections
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SYMMETREL |
| Manufacturer |
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Endo Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Adamantane. |
| Generic Name |
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Amantadine HCl 100mg; tabs. |
| Also |
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• SYMMETREL SYRUP
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| Indications |
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Prophylaxis and treatment of influenza A infections. |
| Children |
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<1yr: not recommended. 1–9yrs: 4.4–8.8mg/kg per day; max 150mg daily. 9–12yrs: 100mg twice daily. Renal dysfunction: reduce dose; see literature. |
| Adults |
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200mg daily in 1–2 divided doses. Elderly: 100mg/day. Renal dysfunction: reduce dose; see literature. |
| Precautions |
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History of seizures. Heart failure. Orthostatic hypotension. Peripheral edema. Renal (CrCl <50mL/min) or hepatic dysfunction. Psychiatric disorders. Suicidal ideation. History of recurrent eczematoid rash. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Caution with CNS stimulants. |
| Adverse Reactions |
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Neuroleptic malignant syndrome (when drug is withdrawn or dose is reduced), nausea, dizziness, insomnia, heart failure, anxiety, irritability, hallucinations, confusion, anorexia, anticholinergic effects, constipation, ataxia, livedo reticularis, peripheral edema, orthostatic hypotension, headache, somnolence, dream abnormality, diarrhea, fatigue. |
| How Supplied |
Tabs—100
Syrup—pt |
| Additional Resources |
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• Related Prescribing Note |
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