Monograph Details
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Infections & Infestations
> Viral infections
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RESCRIPTOR |
| Manufacturer |
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Agouron Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Non-nucleoside reverse transcriptase inhibitor. |
| Generic Name |
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Delavirdine mesylate 100mg, 200mg; tabs. |
| Indications |
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HIV-1 infection. |
| Children |
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<16 years: not recommended. |
| Adults |
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Swallow whole or may disperse 100mg tabs in 3oz water and drink. ≥16 years: 400mg 3 times daily. |
| Precautions |
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Discontinue if serious rash (or rash with other symptoms) occurs. Impaired liver function. Achlorhydria (take with an acidic beverage). Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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See literature. May increase levels of some nonsedating antihistamines, sedative hypnotics (e.g., triazolam, alprazolam, midazolam), antiarrhythmics, dihydropyridine calcium channel blockers (e.g., nifedipine), clarithromycin, dapsone, rifabutin, indinavir, saquinavir (monitor ALT/AST), amprenavir, ergots, amphetamines, cisapride, warfarin, quinidine, sildenafil; serious or life-threatening adverse reactions may occur with some of these drugs (avoid or adjust dose). Delavirdine levels may be decreased by phenytoin, phenobarbital, carbamazepine, rifabutin, rifampin, chronic H2 antagonists, St. John's wort: not recommended; didanosine and vice versa (separate dosing by at least 1 hour). Delavirdine levels increased by clarithromycin, fluoxetine, ketoconazole. Absorption reduced by antacids (separate dosing by at least 1 hour). Reduce indinavir dose (consider indinavir 600mg three times daily). |
| Adverse Reactions |
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Rash, GI upset, increased ALT/AST. |
| How Supplied |
Tabs 100mg—360
200mg—180 |
| Additional Resources |
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• Related Prescribing Note |
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