Monograph Details
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Infections & Infestations
> Viral infections
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INTELENCE |
| Manufacturer |
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Tibotec, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Non-nucleoside reverse transcriptase inhibitor. |
| Generic Name |
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Etravirine 100mg; tabs. |
| Indications |
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HIV-1 infection, in combination with other antiretrovirals, in treatment-experienced adults with evidence of viral replication and HIV-1 strains resistant to an NNRTI and other antiretrovirals. |
| Children |
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Not recommended. |
| Adults |
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Take after meals. May disperse tabs in water and drink. 200mg twice daily. |
| Precautions |
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Severe hepatic impairment. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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Concomitant tipranivir/ritonavir, fosamprenavir/ritonavir, atazanavir/ritonavir, PIs without ritonavir (eg, atazanavir, fosamprenavir, nelfinavir, indinavir), ritonavir (600mg twice daily), NNRTIs (eg, efavirenz, nevirapine, delavirdine): not recommended. Avoid rifampin, rifapentine, St. John's wort, carbamazepine, phenytoin, phenobarbital; rifabutin with darunavir/ritonavir. May affect, or be affected by, drugs that induce or inhibit, or that are substrates of, CYP3A4, CYP2C9, CYP2C19 (eg, azole antifungals, immunosuppressants); monitor. Potentiated by lopinavir/ritonavir. May antagonize antiarrhythmics (eg, amiodarone, bepridil, disopyramide, flecainide, lidocaine, mexiletine, propafenone, quinidine) (monitor), sildenafil. May potentiate warfarin, diazepam. May be antagonized by anticonvulsants, dexamethasone. Clarithromycin (consider azithromycin for treating MAC). Adjust statin dose (except pravastatin, rosuvastatin). Rifabutin (adjust dose with etravirine monotherapy). See literature. |
| Adverse Reactions |
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Rash (may be serious, eg, Stevens-Johnson syndrome, hypersensitivity, erythema multiforme; discontinue if occurs), GI upset, fat redistribution, immune reconstitution syndrome, lab value changes (eg, lipids, blood glucose). |
| Extra Text |
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Note: Report pregnant patients exposed to etravirine by calling (800) 258-4263. |
| How Supplied |
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Tabs—120 |
| Additional Resources |
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• Related Prescribing Note |
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