Monograph Details
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Infections & Infestations
> Viral infections
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FAMVIR |
| Manufacturer |
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Novartis Pharmaceuticals Corp |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Nucleoside analogue. |
| Generic Name |
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Famciclovir (prodrug of penciclovir) 125mg, 250mg, 500mg; tabs. |
| Indications |
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Treatment of acute herpes zoster. Treatment or suppression of recurrent genital herpes and treatment of recurrent herpes labialis (cold sores) in immunocompetent patients. Treatment of recurrent mucocutaneous herpes simplex infections in HIV-infected patients. |
| Children |
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<18yrs: not recommended. |
| Adults |
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≥18years: Herpes zoster: start as soon as herpes zoster is diagnosed (within 72 hrs of onset of rash); treat for 7 days; 500mg every 8 hrs. CrCl 40–59mL/min: 500mg every 12 hrs; CrCl 20–39mL/min: 500mg every 24 hrs; CrCl <20mL/min: 250mg every 24 hrs; hemodialysis (HD): 250mg after each dialysis. Treatment of recurrent genital herpes: begin therapy at first sign or symptom (within 6 hrs); 1000mg every 12 hrs for 1 day; CrCl 40–59mL/min: 500mg every 12 hrs for 1 day; CrCl 20–39mL/min: 500mg single dose; CrCl <20mL/min: 250mg single dose; HD: 250mg after dialysis. Suppression of recurrent genital herpes: 250mg every 12 hrs (for up to 1 year). CrCl 20–39mL/min: 125mg every 12 hrs; CrCl <20mL/min: 125mg every 24 hrs; HD: 125mg after each dialysis. Recurrent herpes labialis: start at first sign or symptom of cold sore: treat with single dose: 1500mg. CrCl 40–59mL/min: 750mg; CrCl 20–39mL/min: 500mg; CrCl <20mL/min: 250mg; HD: 250mg following dialysis. Orolabial or genital herpes simplex in HIV patients: treat for 7 days: 500mg every 12 hrs; CrCl 20–39mL/min: 500mg every 24 hrs; CrCl <20mL/min: 250mg every 24 hrs; HD: 250mg after each dialysis. |
| Precautions |
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Renal dysfunction. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Probenecid, others eliminated by active tubular secretion may increase penciclovir concentrations. May be affected by drugs metabolized by aldehyde oxidase. |
| Adverse Reactions |
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Headache, GI disturbances, fatigue, paresthesia, pruritus. |
| Extra Text |
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Note: Register pregnant patients exposed to famciclovir by calling (888) 669-6682. |
| How Supplied |
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Tabs—30 |
| Additional Resources |
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• Related Prescribing Note |
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