Monograph Details
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Infections & Infestations
> Viral infections
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EMTRIVA ORAL SOLUTION |
| Manufacturer |
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Gilead Sciences, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Nucleoside analogue (reverse transcriptase inhibitor). |
| Generic Name |
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Emtricitabine 10mg/mL; cotton candy flavor. |
| Also |
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• EMTRIVA
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| Indications |
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HIV-1 infection. |
| Children |
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<3months: 3mg/kg once daily. 3months–17yrs: 6mg/kg [max 240mg (24mL)] once daily. >33kg: may use cap form. Renal impairment: reduce dose or prolong dosing interval (see literature). |
| Adults |
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≥18yrs: 240mg (24mL) once daily. Renal impairment: (CrCl 30–49mL/min): 120mg (12mL) once daily; (CrCl 15–29mL/min): 80mg (8mL) once daily; (CrCl <15mL/min): 60mg (6mL) once daily. |
| Precautions |
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Suspend therapy if lactic acidosis or hepatotoxicity (eg, hepatomegaly, steatosis) occurs. Not for treating chronic hepatitis B; test for HBV before starting therapy and closely monitor patients co-infected with HBV and HIV during and for several months after stopping treatment (discontinuing therapy may exacerbate HBV infection). Women, obesity, or prolonged nucleoside exposure, other risk factors for hepatic dysfunction: increased risk of toxicity (eg, lactic acidosis). Renal impairment. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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Avoid concomitant drugs that contain emtricitabine or lamivudine. |
| Adverse Reactions |
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Headache, GI upset, fatigue, dizziness, depression, insomnia, abnormal dreams, rash, abdominal pain, asthenia, increased cough, rhinitis; lactic acidosis, severe hepatomegaly with steatosis, fat redistribution, immune reconstitution syndrome, exacerbation of hepatitis B; also children: skin hyperpigmentation. |
| Extra Text |
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Note: Register pregnant patients exposed to emtricitabine by calling (800) 258-4263. |
| How Supplied |
Caps—30
Soln—170mL |
| Additional Resources |
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• Related Prescribing Note |
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