Monograph Details
|
|
Infections & Infestations
> Viral infections
|
|
CRIXIVAN |
| Manufacturer |
|
Merck & Co., Inc. |
| Legal Classification |
|
Rx
|
| Pharmacological Class |
|
HIV protease inhibitor. |
| Generic Name |
|
Indinavir (as sulfate) 100mg, 200mg, 333mg, 400mg; caps. |
| Indications |
|
HIV infection. |
| Children |
|
Not recommended. Take with water on an empty stomach or with a light meal. 3–18 years: doses of 500mg/m2 every 8 hours have been used; see literature. |
| Adults |
|
Take with water on an empty stomach or with a light meal. 800mg every 8 hours. Concomitant efavirenz: 1g indinavir every 8 hours. Concomitant rifabutin: 1g indinavir every 8 hours and reduce rifabutin dose by ½. Hepatic insufficiency, or concomitant ketoconazole, itraconazole or delavirdine: 600mg indinavir every 8 hours. |
| Contraindications |
|
Concomitant amiodarone, cisapride, triazolam, midazolam, pimozide, ergots. |
| Precautions |
|
Maintain adequate hydration. Discontinue or suspend therapy during acute nephro- or urolithiasis. Impaired hepatic function. Monitor for hyperglycemia. Diabetes. Hemophilia (monitor for spontaneous bleeding). Children (increased risk of nephro- or urolithiasis). Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
|
See Contraindications. Rifampin, St. John's wort, atazanavir, lovastatin, simvastatin: not recommended; caution with other statins metabolized by CYP3A4. Potentiates PDE5 inhibitors; reduce sildenafil to max 25mg per 48 hours; reduce tadalafil to max 10mg per 72 hours; reduce vardenafil to max 2.5mg per 24 hours; rifabutin, calcium channel blockers, others metabolized by CYP3A4. Plasma levels increased by itraconazole, ketoconazole, delavirdine, CYP3A4 inhibitors. Plasma levels reduced by efavirenz, rifabutin; possibly phenobarbital, phenytoin, carbamazepine, dexamethasone, other CYP3A4 inducers. Separate dosing of indinavir and didanosine by at least 1 hour and give both on empty stomach. |
| Adverse Reactions |
|
Nephro- or urolithiasis, asymptomatic hyperbilirubinemia, leukocyturia, GI upset, abdominal pain, headache, fatigue, flank pain, taste perversion, increased cholesterol, hepatitis, hyperglycemia, fat redistribution, renal failure, acute hemolytic anemia, immune reconstitution syndrome. |
| Extra Text |
|
Note: Register pregnant patients exposed to indinavir by calling (800) 258-4263. |
| How Supplied |
Caps 100mg—180
200mg—360
333mg—135
400mg—18, 42, 90, 120, 180 |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
