Monograph Details
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Infections & Infestations
> Tuberculosis
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TRECATOR |
| Manufacturer |
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Wyeth Pharmaceuticals |
| Legal Classification |
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Rx
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| Generic Name |
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Ethionamide 250mg; tabs. |
| Indications |
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Adjunct in tuberculosis, when INH and rifampin are not appropriate. |
| Children |
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Give with meals to minimize GI upset. 10–20mg/kg in 2–3 divided doses, or 15mg/kg once daily. |
| Adults |
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Give with meals to minimize GI upset. Initially 250mg/day in 1–4 divided doses; titrate to highest tolerated dose (see literature). Usual range: 15–20mg/kg daily; max 1g/day. |
| Contraindications |
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Severe hepatic impairment. |
| Precautions |
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Re-titrate when switching from Trecator SC sugar-coated tabs. Give with pyridoxine. Diabetes. Do baseline and periodic blood glucose levels, eye exams (including ophthalmoscopy). Monitor thyroid function. Obtain SGOT and SGPT before and monthly; suspend if levels increase. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Avoid alcohol. Potentiates other antituberculars. Convulsions with cycloserine. |
| Adverse Reactions |
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GI upset, abdominal pain, excessive salivation, metallic taste, stomatitis, anorexia, liver dysfunction, psychosis, drowsiness, dizziness, restlessness, headache, postural hypotension, hypoglycemia, gynecomastia, impotence, acne; rarely; peripheral/optic neuritis, visual disturbances, pellagra, thrombocytopenia. |
| Extra Text |
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Note: Trecator tablets have been reformulated from a sugar-coated tablet to a film-coated tablet which may result in higher peak levels. |
| How Supplied |
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Tabs—100 |
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