Monograph Details
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Infections & Infestations
> Tuberculosis
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Pyrazinamide |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Nicotinamide analogue. |
| Generic Name |
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Pyrazinamide 500mg; scored tabs. |
| Indications |
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Susceptible pulmonary tuberculosis. |
| Adults and Children |
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15–30mg/kg once daily; max 2g daily. Or 50–70mg/kg twice weekly based on lean body weight. |
| Contraindications |
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Severe hepatic damage. Acute gout. |
| Precautions |
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Use with other antituberculars. Monitor hepatic function and serum uric acid before and during therapy. Hepatocellular damage or hyperuricemia with acute gouty arthritis: discontinue. Patients at risk for hepatitis (eg, alcoholism). Diabetes (blood glucose may be harder to control). HIV: see literature. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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May interfere with Acetest or Ketostix. |
| Adverse Reactions |
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Hepatitis, liver dysfunction, gout, GI disturbances, arthralgia, myalgia, blood dyscrasias (rare). |
| How Supplied |
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Contact supplier. |
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