Monograph Details
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Infections & Infestations
> Tuberculosis
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Isoniazid |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Isonicotinic acid. |
| Generic Name |
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Isoniazid 300mg; scored tabs. |
| Indications |
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Prophylaxis and treatment of susceptible tuberculosis. |
| Children |
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Prophylaxis: 10mg/kg once daily; max 300mg daily. Active infection: 10–20mg/kg once daily; max 500mg daily. Do not interrupt therapy. |
| Adults |
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Prophylaxis: 300mg once daily. Active infection: 5mg/kg daily; max 300mg once daily. Do not interrupt therapy. |
| Contraindications |
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Previous isoniazid-associated hepatic injury. Acute hepatic disease. |
| Precautions |
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Impaired renal or hepatic function. Monitor hepatic and ocular function. Alcoholism. Diabetes. Increased risk of liver damage with increasing age. Multiple drug therapy and concomitant pyridoxine may be necessary. Pregnancy. Nursing mothers. |
| Interactions |
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Potentiates phenytoin. Alcohol increases risk of hepatitis. Pyridoxine deficiency increases risk of neuropathy. |
| Adverse Reactions |
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Hepatitis, peripheral neuropathy, hepatic injury, GI distress, blood dyscrasias, pyridoxine deficiency, hyperglycemia, rheumatic and SLE-like syndrome. |
| How Supplied |
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Contact supplier. |
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