Monograph Details
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Infections & Infestations
> Protozoal infections
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TINDAMAX |
| Manufacturer |
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Mission Pharmacal Company |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Nitroimidazole. |
| Generic Name |
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Tinidazole 250mg, 500mg; scored tabs. |
| Indications |
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Giardiasis. Intestinal amebiasis. Amebic liver abscess. |
| Children |
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<3yrs: not recommended. Take with food. ≥3yrs: Giardiasis: 50mg/kg (max 2g) as a single dose. Intestinal amebiasis: 50mg/kg (max 2g) per day for 3 days. Amebic liver abscess: 50mg/kg (max 2g) per day for 3–5 days. |
| Adults |
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Take with food. Giardiasis: 2g as a single dose. Intestinal amebiasis: 2g once daily for 3 days. Amebic liver abscess: 2g once daily for 3–5 days. Hemodialysis: see literature. |
| Contraindications |
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Pregnancy (1st trimester). |
| Precautions |
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CNS disorders. Discontinue if neurological effects occur. Hepatic dysfunction. Candidiasis. Blood dyscrasias. Monitor leukocytes before and after therapy. Elderly. Pregnancy (Cat.C) (2nd and 3rd trimesters). Nursing mothers: not recommended during and for 3 days after last dose. |
| Interactions |
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Avoid alcohol during and for 3 days after use. Do not give within 2 weeks of disulfiram. May potentiate oral anticoagulants, lithium, phenytoin. Monitor cyclosporine, tacrolimus, fluorouracil. May be antagonized by CYP450 inducers (eg, phenobarbital, rifampin), others. May be potentiated by CYP450 inhibitors (eg, cimetidine, ketoconazole). May interfere with serum chemistry tests. |
| Adverse Reactions |
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GI upset, abdominal pain, metallic taste, anorexia, constipation, fatigue, dizziness, headache, transient leukopenia/neutropenia; rare: seizures, peripheral neuropathy. |
| How Supplied |
Tabs 250mg—40
Tabs 500mg—20, 60 |
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