Monograph Details
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Infections & Infestations
> Protozoal infections
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FLAGYL 375 |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Nitroimidazole. |
| Generic Name |
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Metronidazole 375mg; caps. |
| Also |
• FLAGYL
• FLAGYL I.V. INJECTION
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| Indications |
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Amebic dysentery. Amebic liver abscess. |
| Children |
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35–50mg/kg/day in 3 divided doses for 10 days. |
| Adults |
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Dysentery: 750mg. Abscess: 500–750mg. Both: 3 times daily for 5–10 days. |
| Contraindications |
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Pregnancy (1st trimester for trichomoniasis). |
| Precautions |
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CNS disease. Discontinue if neurologic symptoms occur. Severe hepatic disease: reduce dose. History of blood dyscrasias. Candidiasis. Monitor leukocytes before and after therapy. Elderly: monitor serum levels. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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Avoid alcohol during and for 3 days after use. Do not give within 2 weeks of disulfiram (possible psychotic reactions). May potentiate oral anticoagulants, phenytoin, lithium. Antagonized by phenobarbital, phenytoin, other hepatic enzyme inducers. May impair phenytoin clearance. Potentiated by cimetidine, other hepatic enzyme inhibitors. Interferes with serum chemistry tests. |
| Adverse Reactions |
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Seizures, peripheral neuropathy, GI upset, anorexia, constipation, headache, metallic taste, ECT changes, dysuria. |
| How Supplied |
Tabs—50, 100
Caps 375mg—50 |
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