Monograph Details
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Infections & Infestations
> Protozoal infections
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ARALEN |
| Manufacturer |
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Sanofi Aventis |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Aminoquinoline. |
| Generic Name |
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Chloroquine phosphate 500mg; tabs. |
| Indications |
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Extraintestinal amebiasis (use with intestinal amebicide). |
| Children |
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See literature. |
| Adults |
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1g daily for 2 days, then 500mg daily for at least 2–3 wks. |
| Contraindications |
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Retinal or visual field changes. |
| Precautions |
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Suppression: start 2 wks before and continue for 8 wks after trip. Hepatic or auditory dysfunction. Alcoholism. Psoriasis. Porphyria. Seizure disorders. G6PD deficiency. Discontinue if hematologic, visual disorders or ototoxicity occurs. Monitor CBC, reflexes, vision in long-term use. Elderly. Children. Pregnancy (use adequate contraception in endemic areas). Nursing mothers: not recommended. |
| Interactions |
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Avoid cimetidine. Separate ampicillin dose by 2 hours; dosing of antacids, kaolin by 4 hours. Potentiates cyclosporine (monitor). Caution with hepatotoxic drugs. |
| Adverse Reactions |
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Retinopathy, headache, pruritus, photosensitivity, GI or CNS disturbances (eg, seizures, psychosis, tinnitus, visual changes) blood dyscrasias, neuromyopathy, cardiomyopathy. |
| How Supplied |
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Tabs—25 |
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