Monograph Details
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Infections & Infestations
> Malaria
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VIBRAMYCIN |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Tetracycline. |
| Generic Name |
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Doxycycline (as hyclate) 50mg, 100mg; caps. |
| Also |
• VIBRA-TABS
• VIBRAMYCIN SUSPENSION
• VIBRAMYCIN SYRUP
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| Indications |
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Short term prophylaxis of P. falciparum. |
| Children |
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Under 8 yrs: not recommended. Over 8 yrs: 2mg/kg daily; max 100mg daily; begin 1–2 days before, continue during and 4 weeks after travel to malarious area. |
| Adults |
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100mg daily; begin 1–2 days before, continue during and 4 weeks after travel to malarious area. |
| Precautions |
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Monitor blood, renal, and hepatic function in long-term use. Avoid sun and UV light. Asthma (syrup). Pregnancy (Cat.D), nursing mothers: not recommended. |
| Interactions |
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May increase digoxin levels. Antacids, iron, zinc, calcium, magnesium, urinary alkalinizers reduce absorption. Avoid concomitant penicillins, methoxyflurane. Carbamazepine, hydantoins may decrease effectiveness. Monitor prothrombin time with oral anticoagulants. Oral contraceptives may be less effective. |
| Adverse Reactions |
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Photosensitivity, GI upset, rash, blood dyscrasias, hepatotoxicity. |
| How Supplied |
Caps 50mg—50
100mg—50, 500
Syrup—1oz, pt
Susp—2oz
Tabs—50, 500 |
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