Monograph Details
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Infections & Infestations
> Malaria
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QUALAQUIN |
| Manufacturer |
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AR Scientific |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Quinoline (cinchona alkaloids). |
| Generic Name |
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Quinine sulfate 324mg; caps. |
| Indications |
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Treatment of uncomplicated P. falciparum malaria (including chloroquine-resistant strains). |
| Children |
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<16yrs: not recommended. |
| Adults |
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Take with food. ≥16yrs: 648mg every 8 hrs for 7 days. Severe renal failure: 648mg once, after 12 hrs start 324mg every 12 hrs. |
| Contraindications |
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Prolonged QT interval. G6PD deficiency. Myasthenia gravis. Mefloquine, quinidine or related allergy. History of thrombocytopenic purpura, hemolytic uremic syndrome, thrombocytopenia, blackwater fever associated with previous quinine use. Optic neuritis. |
| Precautions |
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Discontinue if any signs or symptoms of hypersensitivity occurs (eg, thrombocytopenic purpura, hemolytic uremic syndrome, thrombocytopenia, blackwater fever). Hepatic or renal impairment. Cardiac arrhythmias. Atrial fibrillation or atrial flutter. Hypoglycemia. Hypokalemia. Bradycardia. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Avoid drugs that can prolong QT interval (eg, quinidine, procainamide, disopyramide, amiodarone, sotalol, dofetilide), other CYP3A4 substrates (eg, cisapride, pimozide, halofantrine, quinidine), erythromycin, troleandomycin. Avoid concomitant antimalarials, mefloquine, halofantrine (may cause seizures or ECG changes), antacids. Potentiates anticoagulants, neuromuscular blocking agents. Potentiated by urinary alkalizers. May antagonize anticonvulsants (eg, carbamazepine, phenobarbital, phenytoin), CYP2D6 substrates (eg, flecainide, metoprolol, paroxetine, dextromethorphan). Antagonized by rifampin. Increases digoxin levels (monitor). Monitor cimetidine, ketoconazole. |
| Adverse Reactions |
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Headache, ototoxicity, dizziness, GI upset, visual disturbances, lupus-like syndrome, blood dyscrasias, rashes (may be serious eg, Stevens-Johnson), cardiovascular effects (eg, chest pain, AV block, torsades de pointes), hypoglycemia (esp. in pregnancy). |
| How Supplied |
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Caps—30, 100, 500, 1000 |
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