Monograph Details
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Infections & Infestations
> Fungal infections
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MEPRON |
| Manufacturer |
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GlaxoSmithKline Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Naphthoquinone. |
| Generic Name |
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Atovaquone 750mg/5mL; susp; citrus flavor. |
| Indications |
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Treatment of mild to moderate Pneumocystis carinii pneumonia (PCP) in patients intolerant to trimethoprim/sulfamethoxazole (TMP/SMX). Prevention of PCP in patients intolerant to TMP/SMX. |
| Children |
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See literature. |
| Adults |
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Take with food. Treatment: 750mg twice daily for 21 days. Prophylaxis: 1500mg once daily. |
| Precautions |
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GI disorders or inability to take with food. Monitor in severe hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Antagonized by rifampin. Caution with other highly protein-bound drugs. |
| Adverse Reactions |
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Rash, headache, GI upset, dyspnea, cough, rhinitis, infection, fever, elevated liver enzymes, insomnia, asthenia, oral moniliasis, pruritus, sinusitis, anorexia, depression, myalgia, pancreatitis, thrombocytopenia, allergic reactions. |
| How Supplied |
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Susp—210mL |
| Additional Resources |
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• Related Prescribing Note |
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