Monograph Details
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Infections & Infestations
> Fungal infections
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AMPHOTEC |
| Manufacturer |
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Three Rivers Pharmaceuticals, LLC |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Polyene. |
| Generic Name |
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Amphotericin B cholesteryl sulfate complex 50mg/vial, 100mg/vial; pwd for IV infusion after reconstitution and dilution. |
| Indications |
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Invasive aspergillosis in patients who are refractory to, or intolerant of, conventional amphotericin B therapy. |
| Adults and Children |
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See literature. Give test dose first. Initially 3–4mg/kg once daily as needed. Infuse at 1mg/kg/hr over at least 2 hrs (or longer if warranted). |
| Precautions |
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Pretreat with corticosteroids, antihistamines, and/or decrease infusion rate to minimize infusion reactions. Monitor renal and hepatic function, CBC, PT, electrolytes (esp. K+ with concomitant digoxin). Stop infusion if severe respiratory distress occurs. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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Antineoplastics may potentiate renal toxicity, bronchospasm, hypotension. Corticosteroids, ACTH may potentiate hypokalemia. Cyclosporine, tacrolimus, aminoglycosides, pentamidine may increase renal toxicity. May increase flucytosine toxicity. May antagonize ketoconazole, fluconazole, other imidazoles. |
| Adverse Reactions |
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Infusion reactions (chills, fever, hypo- or hypertension, tachypnea), GI upset, abnormal liver function test, headache, thrombocytopenia, hypokalemia, hypomagnesemia, bilirubinemia, increased creatinine and alkaline phosphatase, hypocalcemia, hyperglycemia, dyspnea, hypoxia, sweating, others. |
| How Supplied |
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Single-dose vials—1 |
| Additional Resources |
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• Related Prescribing Note |
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