Monograph Details
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Infections & Infestations
> Bacterial infections
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ZINACEF |
| Manufacturer |
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GlaxoSmithKline Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Cephalosporin. |
| Generic Name |
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Cefuroxime (as sodium) 750mg, 1.5g; IM or IV inj; sodium content 2.4mEq/g. |
| Indications |
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Susceptible bacterial septicemia, lower respiratory or urinary tract, skin and skin structure, meningitis, bone and joint infections, gonorrhea. Surgical prophylaxis. |
| Children |
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<3 months: not recommended. Give in equally divided doses. ≥3 months: usual range: 50–100mg/kg per day every 6–8 hours. Bone and joint: 150mg/kg per day every 8 hours. Meningitis: 200–240mg/kg per day IV every 6–8 hours. Renal dysfunction: reduce dose. |
| Adults |
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Use IV route for serious infections. Usual duration of therapy: 5–10 days. Uncomplicated UTIs, skin and skin structure, disseminated gonorrhea, or uncomplicated pneumonia: 750mg every 8 hours. Severe or complicated infections, bone and joint: 1.5g every 8 hours; life-threatening: 1.5g every 6 hours; meningitis: max 3g every 8 hours. Uncomplicated gonorrhea: 1.5g IM once (divide into 2 injections) with 1g oral probenecid. Prophylaxis: see literature. Renal dysfunction: CrCl 10–20mL/min: 750mg every 12 hours; CrCl <10mL/min: 750mg every 24 hours. Coincide a dose for end of dialysis. |
| Precautions |
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Penicillin allergy. Renal impairment, reduce dose. Monitor prothrombin time (in patients at risk), renal function. GI disease (esp. colitis). Elderly. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Avoid aminoglycosides, furosemide, ethacrynic acid, other nephrotoxic drugs. May cause false (+) glucose test with Clinitest, Benedict's or Fehling's soln. Potentiated by probenecid. |
| Adverse Reactions |
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Local reactions, blood dyscrasias, elevated liver enzymes; rarely: GI upset, rash (may be serious, eg, Stevens-Johnson syndrome), drug fever, anaphylaxis, interstitial nephritis, seizures, hearing loss in children treated for meningitis. |
| How Supplied |
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Vials—10 |
| Additional Resources |
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• Related Prescribing Note |
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