Monograph Details
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Infections & Infestations
> Bacterial infections
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UNASYN |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Broad-spectrum penicillin + β-lactamase inhibitor. |
| Generic Name |
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Ampicillin sodium 1g, sulbactam sodium 0.5g (1.5g vial); or ampicillin sodium 2g, sulbactam sodium 1g (3g vial); IM or IV inj; sodium content 5mEq/g of ampicillin. |
| Indications |
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Susceptible skin and skin structure, intraabdominal, gynecologic infections. |
| Children |
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Intraabdominal infections: not recommended. Dose is given as ampicillin + sulbactam. <1yr: not recommended. ≥1yr (<40kg): 300mg/kg per day IV in equally divided doses every 6 hrs; usual max 14 days. ≥40kg: as adult. |
| Adults |
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Dose is given as ampicillin + sulbactam. Normal renal function (CrCl ≥30mL/min): 1.5–3g IM or IV every 6 hours; CrCl 15–29mL/min: 1.5–3g every 12 hrs; CrCl 5–14mL/min: 1.5–3g every 24 hrs. |
| Precautions |
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Cephalosporin, imipenem, other allergy or mononucleosis: not recommended. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Potentiated by probenecid. Increased incidence of rash with allopurinol. May cause false (+) Clinitest, Benedict's or Fehling's soln. |
| Adverse Reactions |
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Inj site reactions, diarrhea, rash, blood dyscrasias, anaphylaxis, elevated liver enzymes. |
| How Supplied |
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Vials (1.5g, 3g)—1 |
| Additional Resources |
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• Related Prescribing Note |
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