Monograph Details
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Infections & Infestations
> Bacterial infections
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ROCEPHIN |
| Manufacturer |
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Roche Laboratories |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Cephalosporin. |
| Generic Name |
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Ceftriaxone sodium 250mg, 500mg, 1g, 2g; IM or IV inj; sodium content 3.6mEq/g. |
| Indications |
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Susceptible bacterial septicemia, acute bacterial otitis media, lower respiratory tract, UTIs, skin and skin structure, bone and joint, pelvic inflammatory disease (PID), intraabdominal infections, meningitis, uncomplicated gonorrhea. Surgical prophylaxis. |
| Children |
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50–75mg/kg per day in equally divided doses every 12 hours; max 2g/day. Skin and skin structures: may give as a single dose or in 2 equally divided doses every 12 hours; max 2g/day. Meningitis: 100mg/kg (max 4g) for 1 dose, then 100mg/kg per day (max 4g/day) once daily or in 2 equally divided doses every 12 hours for 7–14 days. Otitis media: 50mg/kg (max 1g) IM once. |
| Adults |
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1–2g IM or IV once daily or in 2 equally divided doses; max 4g/day. Gonorrhea: 250mg IM once. Surgery: 1g IV ½–2 hours pre-op. |
| Contraindications |
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Hyperbilirubinemic neonates (esp. prematures). Concomitant calcium-containing solutions or products in newborns. |
| Precautions |
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Penicillin or other allergy. Discontinue if gallbladder sonographic abnormalities, symptoms or disease occur. Renal failure: monitor; decrease dose if drug accumulation occurs. Chronic hepatic disease or malnutrition (impaired Vit. K synthesis or storage), monitor prothrombin time. Both renal and hepatic impairment: usual max 2g/day. GI disease (esp. colitis). Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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See Contraindications. Potentiated by probenecid. |
| Adverse Reactions |
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Inj site reactions, hematologic effects (eg, eosinophilia), rash, diarrhea, elevated liver enzymes; rare: allergic pneumonitis, seizures, anaphylaxis. |
| How Supplied |
Vials (250mg, 500mg, 1g)—1, 10
Vials (2g)—10 |
| Additional Resources |
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• Related Prescribing Note |
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