Monograph Details
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Infections & Infestations
> Bacterial infections
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RIFADIN |
| Manufacturer |
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Sanofi Aventis |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Rifamycin. |
| Generic Name |
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Rifampin 150mg, 300mg; caps. |
| Also |
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• RIFADIN IV INJECTION
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| Indications |
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Asymptomatic carriers of Neisseria meningitidis to eliminate meningococci from nasopharynx. |
| Children |
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<1 month: 5mg/kg every 12 hours for 4 doses. ≥1 month: 10mg/kg every 12 hours for 4 doses; max 600mg/day. Oral: give 1 hour before or 2 hours after meals. See literature for preparation of susp. |
| Adults |
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600mg 2 times a day for 4 doses. Oral: give 1 hour before or 2 hours after meals. |
| Precautions |
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Reserve drug for cases where high risk of meningococcal meningitis exists. Confirm diagnosis. Impaired hepatic function. May stain body secretions and contact lenses. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Reduces serum levels of protease inhibitors: avoid concomitant use. Antagonizes anticoagulants, cardiac glycosides, oral hypoglycemics, oral contraceptives, others (by inducing metabolic enzymes). Avoid use within 8 hours of PAS. Concomitant ketoconazole decreases serum concentration of both drugs. |
| Adverse Reactions |
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Hepatitis, jaundice, GI upset, headache, drowsiness, ataxia, dizziness, confusion, visual disturbances, muscular weakness, fever, urticaria, blood dyscrasias. |
| How Supplied |
150mg—30
300mg—30, 60, 100
Vials—1 |
| Additional Resources |
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• Related Prescribing Note |
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