Monograph Details
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Infections & Infestations
> Bacterial infections
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PROQUIN XR |
| Manufacturer |
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Depomed, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Quinolone. |
| Generic Name |
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Ciprofloxacin (as HCl) 500mg; ext-rel tabs. |
| Indications |
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Susceptible uncomplicated UTIs. |
| Children |
<18yrs: not recommended.
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| Adults |
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Swallow whole. Take with PM meal. ≥18yrs: 500mg once daily for 3 days. |
| Precautions |
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Not interchangeable with other forms of ciprofloxacin. Increased risk of tendinitis and tendon rupture esp. in patients >60yrs, or those with kidney, heart or lung transplants. Discontinue if tendon pain, inflammation, or rupture occurs; if rash, phototoxicity, or other sign of hypersensitivity occurs; or if CNS effects or neuropathy occurs. Conditions that increase seizure risk. Severe renal impairment. Acute hepatic insufficiency. History of joint-related disorders or QT prolongation. Maintain adequate hydration, avoid alkaline urine to avoid crystalluria. Avoid excessive sun and UV light. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Avoid theophylline (increases theophylline levels; may potentiate other CYP1A2 substrates), urinary alkalinizers; antacids, calcium, iron, zinc, sucralfate, buffered forms of didanosine, other highly buffered drugs (give 4 hours before or 2 hours after these); high ciprofloxacin doses with NSAIDs (increases seizure risk). Potentiates caffeine. Potentiated by probenecid. Severe hypoglycemia with glyburide (rare). Increased serum creatinine with cyclosporine. Increased risk of tendinitis and tendon rupture with corticosteroids. Monitor methotrexate, oral anticoagulant (potentiation), phenytoin (variable effects). Caution with class IA, class III antiarrhythmics (esp. elderly), drugs that lower seizure threshold. See literature. |
| Adverse Reactions |
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Headache, GI upset, fungal infection, nasopharyngitis, micturition urgency, CNS disturbances (eg, convulsions, dizziness, nervousness, insomnia, nightmares, paranoia), rash, photosensitivity, tendinitis/rupture, rare: peripheral neuropathy. |
| How Supplied |
Tabs—30
Blister pack—3 |
| Additional Resources |
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• Related Prescribing Note |
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