Monograph Details
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Infections & Infestations
> Bacterial infections
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PCE |
| Manufacturer |
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Abbott Laboratories |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Macrolide. |
| Generic Name |
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Erythromycin (as base) 333mg, 500mg; particles in tabs. |
| Indications |
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Susceptible infections including upper and lower respiratory, skin and soft tissue, genitourinary, Legionnaires' disease, pertussis, listeriosis. |
| Children |
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Preferably give 2 hours before meals. Mild-to-moderate infections: 30–50mg/kg/day; may double dose in severe infections. Both in divided doses. Max 4g daily. |
| Adults |
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Preferably take 2 hours before meals. Usually 333mg every 8 hours or 500mg every 12 hours. Genitourinary: two 333mg tabs every 8 hours or 500mg 4 times daily for 7 days. Legionnaires: 1–4g daily in divided doses. Max 4g daily; twice daily dosing max 1g/day. |
| Contraindications |
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Concomitant cisapride, pimozide. |
| Precautions |
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Hepatic dysfunction. Myasthenia gravis. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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See Contraindications. May potentiate or be potentiated by drugs metabolized by CYP450 (e.g., carbamazepine, cyclosporine, tacrolimus, hexobarbital, phenytoin, alfentanil, disopyramide, bromocriptine, valproate). May potentiate warfarin, triazolam, midazolam, methylprednisolone, digoxin, theophylline, ergotamine. Avoid use with statins (rhabdomyolysis). |
| Adverse Reactions |
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GI upset, abdominal pain, anorexia, hepatic dysfunction, rash. |
| How Supplied |
Tabs 333mg—60
500mg—100 |
| Additional Resources |
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• Related Prescribing Note |
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