Monograph Details
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Infections & Infestations
> Bacterial infections
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Nafcillin Inj |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Penicillinase-resistant penicillin. |
| Generic Name |
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Nafcillin sodium 1g/vial, 2g/vial, 10g/vial; pwd for deep IM inj after reconstitution, IV inj or IV drip after reconstitution and dilution. |
| Indications |
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Susceptible infections due to penicillinase-producing staphylococci. |
| Children |
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Give by deep IM gluteal inj only. Neonates: 10mg/kg twice daily. Infants and children <40kg: 25mg/kg twice daily. |
| Adults |
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Give by deep IM gluteal inj, or IV inj over 5–10 mins, or short-term IV drip for 24–48 hours. IM: 500mg every 4–6 hours. IV: 500mg every 4 hours. Severe infections: 1g IM or IV every 4 hours; treat for at least 14 days, then continue for at least 48 hours after becoming afebrile, asymptomatic, or (–) cultures. Endocarditis or osteomyelitis: may need longer therapy; see literature. Switch to oral therapy as soon as clinically indicated. |
| Precautions |
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Cephalosporin or other allergy: not recommended. Asthma. Renal impairment: consider dose reduction. Do CBCs, BUN, urinalysis, creatinine levels prior to and weekly during therapy. Monitor renal, hepatic and hematopoietic function in prolonged use. Elderly (esp. IV route). Newborns (monitor). Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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May be antagonized by tetracycline; avoid. Potentiated by probenicid. |
| Adverse Reactions |
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Inj site reactions, rash, serum sickness, GI upset, anaphylaxis, neuropathy, nephropathy, blood dyscrasias. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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