Monograph Details
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Infections & Infestations
> Bacterial infections
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MONODOX |
| Manufacturer |
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Oclassen Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Tetracycline. |
| Generic Name |
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Doxycycline monohydrate 50mg, 100mg; caps. |
| Indications |
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Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma. Postexposure prophylaxis and treatment of anthrax. |
| Children |
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<8 years: usually not recommended. ≥8 years (≤100lbs): 2mg/lb divided in 2 doses for 1 day; then 1–2mg/lb daily in 1–2 doses; max 2mg/lb daily. >100lbs: 100 mg orally every 12 hours. Postexposure prophylaxis of inhalational anthrax, or treatment of cutaneous anthrax: >8 years (>45kg): as adult; >8 years (≤45kg) or ≤8 years: 2.2 mg/kg orally every 12 hours. Treatment of inhalational, GI, or oropharyngeal anthrax, or cutaneous anthrax with systemic involvement, extensive edema, or head/neck lesions: >8 years (>45kg): use an IV form first at 100 mg every 12 hours (w. 1 or 2 other antimicrobials), then switch to oral form at same dose; >8 years (≤45kg) or ≤8 years: 2.2 mg/kg IV every 12 hours (w. 1 or 2 other antimicrobials), then switch to oral form at same dose. Treat for a total of 60 days. |
| Adults |
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Take with fluids. 100mg every 12 hours for 1 day; then 100mg daily; max 200mg daily. Postexposure prophylaxis of inhalational anthrax, or treatment of cutaneous anthrax: 100mg orally every 12 hours (start as soon as possible after exposure). Treatment of inhalational, GI, or oropharyngeal anthrax, or cutaneous anthrax with systemic involvement, extensive edema, or head/neck lesions: use an IV form initially at 100mg IV every 12 hours (w. 1 or 2 other antimicrobials), then switch to oral form at 100mg every 12 hours. Treat for a total of 60 days. |
| Precautions |
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Monitor blood, renal, and liver function in long-term use. Sunlight or UV light. Pregnancy (Cat.D), nursing mothers: usually not recommended. |
| Interactions |
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Antacids, iron, zinc, calcium, magnesium reduce absorption. Avoid concomitant methoxyflurane. Carbamazepine, phenytoin, barbiturates may decrease effectiveness. Monitor prothrombin time with oral anticoagulants. |
| Adverse Reactions |
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Photosensitivity, GI upset, rash, blood dyscrasias, hepatotoxicity. |
| Extra Text |
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Note: See MMWR Vol 50, No.42 (Oct. 26, 2001) for more information on anthrax. |
| How Supplied |
Caps 50mg—100
100mg—50, 250 |
| Additional Resources |
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• Related Prescribing Note |
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