Monograph Details
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Infections & Infestations
> Bacterial infections
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MERREM |
| Manufacturer |
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AstraZeneca Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Carbapenem. |
| Generic Name |
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Meropenem 500mg, 1g; pwd for IV inj after reconstitution; sodium content 3.92mEq/g. |
| Indications |
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Susceptible infections including complicated skin and skin structure, intraabdominal infections, bacterial meningitis. |
| Children |
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Give by IV infusion over 15–30 mins or IV bolus over 3–5 mins. <3 months: not recommended. ≥3 months: Skin and skin structure: 10mg/kg (max 500mg) every 8hrs. Intraabdominal: 20mg/kg (max 1g) every 8hrs. Meningitis: 40mg/kg (max 2g) every 8hrs. |
| Adults |
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Give by IV infusion over 15–30 mins or IV bolus over 3–5 mins (for doses = 1g). Skin and skin structure: 500mg every 8hrs. Intraabdominal: 1g every 8hrs. Renal impairment: CrCl 26–50mL/min: give recommended dose every 12hrs; CrCl 10–25mL/min: give ½ of recommended dose every 12hrs; CrCl <10mL/min: give ½ of recommended dose every 24hrs. |
| Contraindications |
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Penicillin, cephalosporin, or other β-lactam allergy. |
| Precautions |
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CNS disorders. History of seizures. Renal impairment. Monitor renal, hepatic, and hematopoietic function in long-term use. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Potentiated by probenecid: not recommended. May antagonize valproic acid. |
| Adverse Reactions |
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Local reactions, GI upset, headache, rash, pruritus, apnea, constipation, sepsis, anemia, pain. |
| How Supplied |
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Single-use vials—1 |
| Additional Resources |
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• Related Prescribing Note |
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