Monograph Details
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Infections & Infestations
> Bacterial infections
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MAXIPIME |
| Manufacturer |
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Elan Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Cephalosporin. |
| Generic Name |
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Cefepime (as HCl) 500mg, 1g, 2g; pwd for IV infusion or IM inj after reconstitution. |
| Indications |
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Susceptible infections, including moderate-to-severe pneumonia, uncomplicated skin and skin structure infections, complicated and uncomplicated urinary tract infections (UTIs) including pyelonephritis, complicated intraabdominal in adults (w. metronidazole). Empiric therapy in febrile neutropenia. |
| Children |
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<2months: not recommended. Not for use in serious infection when pathogen is or may be H. influenzae type b. 2months–16yrs (≤40kg): 50mg/kg per dose, given every 12 hrs; do not exceed recommended adult dose. Severe UTIs, pneumonia, skin and skin structure: give IV for 10 days. Mild-to-moderate UTIs: give IV or IM for 7–10 days (IM only for UTIs caused by E. coli). Febrile neutropenia: give IV every 8 hours for 7 days or until neutropenia resolves. |
| Adults |
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When giving IV, infuse over 30 minutes. Pneumonia: 1–2g IV every 12 hrs for 10 days. Skin and skin structures, severe UTIs: 2g IV every 12 hrs for 10 days. Mild-to-moderate UTIs: 500mg–1g IV or IM every 12 hrs for 7–10 days (IM only for UTIs caused by E. coli). Intraabdominal (use w. metronidazole): 2g IV every 12 hrs for 7–10 days. Febrile neutropenia: 2g IV every 8 hrs for 7 days or until neutropenia resolves. CrCl ≤60mL/min: reduce dose; see literature. Hemodialysis: repeat initial dose after each session. Continuous ambulatory peritoneal dialysis: give usual doses at 48-hour intervals. |
| Contraindications |
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Penicillin or other β-lactam allergy. |
| Precautions |
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Renal impairment. Renal or hepatic dysfunction, poor nutritional state, prolonged antimicrobial therapy: monitor prothrombin time. History of GI disease (esp. colitis). Labor & delivery. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Aminoglycosides may potentiate oto- or nephrotoxicity. Possible nephrotoxicity with diuretics (e.g., furosemide). May cause false (+) Coomb's, Clinitest. |
| Adverse Reactions |
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Local reactions (e.g., pain, phlebitis, inflammation), rash, GI disturbances, pruritus, fever, headache, seizures, blood dyscrasias, anemia, renal dysfunction, others. |
| How Supplied |
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Vials (500mg, 1g, 2g)—10 |
| Additional Resources |
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• Related Prescribing Note |
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