Monograph Details
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Infections & Infestations
> Bacterial infections
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MACRODANTIN |
| Manufacturer |
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Procter & Gamble Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Antibiotic. |
| Generic Name |
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Nitrofurantoin macrocrystals 25mg, 50mg, 100mg; caps. |
| Indications |
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Susceptible UTIs. |
| Children |
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Take with food. <1month: not recommended. ≥1month: 5–7mg/kg per day in 4 divided doses for at least 7 days. Long-term use: 1mg/kg per day in 1–2 divided doses. |
| Adults |
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Take with food. 50–100mg 4 times a day for at least 7 days. Long-term use: 50–100mg at bedtime. |
| Contraindications |
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Anuria, oliguria, creatinine clearance <60mL/min. Neonates <1 month of age. Labor & delivery. Pregnancy at term. Nursing mothers. |
| Precautions |
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Renal insufficiency. G6PD or Vit. B deficiency. Anemia. Diabetes. Electrolyte imbalance. Asthma. Discontinue if pulmonary, hepatic disorders, hemolysis, or peripheral neuropathy occur. Monitor renal function in long-term use. Debilitated. Pregnancy (Cat.B). |
| Interactions |
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Avoid antacids containing magnesium trisilicate. May be antagonized by uricosurics. May cause false (+) glucose test with Benedict's or Fehling's solution. |
| Adverse Reactions |
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GI disturbances, headache, pulmonary disorders, hepatic damage, peripheral neuropathy, hemolytic anemia, dizziness, anorexia, alopecia, exfoliative dermatitis, Stevens-Johnson syndrome, anaphylaxis, blood dyscrasias, aplastic anemia. |
| How Supplied |
Caps 25mg—100
50mg, 100mg—100, 500, 1000 |
| Additional Resources |
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• Related Prescribing Note |
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