Monograph Details
|
|
Infections & Infestations
> Bacterial infections
|
|
MACROBID |
| Manufacturer |
|
Procter & Gamble Pharmaceuticals |
| Legal Classification |
|
Rx
|
| Pharmacological Class |
|
Antibiotic. |
| Generic Name |
|
Nitrofurantoin (as macrocrystals and monohydrate) 100mg; caps. |
| Indications |
|
Susceptible acute uncomplicated UTIs. |
| Children |
|
Not recommended. |
| Adults |
|
Take with meals. 100mg every 12hrs for 7 days. |
| Contraindications |
|
Anuria, oliguria, creatinine clearance <60mL/min. Neonates <1 month of age. Labor & delivery. Pregnancy at term. Nursing mothers. |
| Precautions |
|
Renal insufficiency. G6PD or Vit. B deficiency. Anemia. Diabetes. Electrolyte imbalance. Asthma. Discontinue if pulmonary, hepatic disorders, hemolysis, or peripheral neuropathy occur. Monitor renal function in long-term use. Debilitated. Pregnancy (Cat.B). |
| Interactions |
Avoid antacids containing magnesium trisilicate. May be antagonized by uricosurics (e.g., probenecid).
May cause false (+) glucose test with Benedict's or Fehling's solution. |
| Adverse Reactions |
|
GI disturbances, headache, pulmonary disorders, hepatic damage, peripheral neuropathy, hemolytic anemia, dizziness, anorexia, alopecia, exfoliative dermatitis, Stevens-Johnson syndrome, anaphylaxis, blood dyscrasias, aplastic anemia. |
| How Supplied |
|
Caps—100 |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
