Monograph Details
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Infections & Infestations
> Bacterial infections
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INVANZ |
| Manufacturer |
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Merck & Co., Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Carbapenem. |
| Generic Name |
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Ertapenem (as sodium) 1g; pwd for IV infusion after reconstitution and dilution; or for IM inj after reconstitution; sodium content 6mEq/g. |
| Indications |
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Susceptible moderate to severe infections including complicated intraabdominal, complicated skin and skin structure, community-acquired pneumonia, complicated UTIs, acute pelvic infections. |
| Adults and Children |
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Give by IV infusion over 30 minutes for up to 14 days; or, give by IM inj for up to 7 days (for IM: see note). <3months: not recommended. 3months–12yrs: 15mg/kg twice daily (max 1g/day). ≥13yrs: 1g once daily; renal dysfunction (CrCl ≤30mL/min): 500mg once daily (give supplemental 150mg after session if dosed within 6 hours of hemodialysis). Intraabdominal: treat 5–14 days. Skin and skin structure: treat 7–14 days. Pneumonia, UTIs: treat 10–14 days (may switch to oral antibiotic after 3 days). Pelvic: treat 3–10 days. |
| Contraindications |
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Penicillin, cephalosporin, or other β-lactam allergy. |
| Precautions |
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CNS disorders (eg, brain lesions, seizure history). Renal dysfunction. Avoid extravasation. Monitor renal, hepatic, and hematopoetic function in prolonged use. Elderly. Labor & delivery. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Potentiated by probenecid: not recommended. |
| Adverse Reactions |
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GI upset, inj site reactions (thrombophlebitis/phlebitis), headache, CNS effects (dizziness, altered mental state, rarely: seizures), edema, dyspnea, fever. |
| Extra Text |
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Note: For IM use, reconstitute with lidocaine 1% only; see literature. |
| How Supplied |
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Vials (1g)—10, 25 |
| Additional Resources |
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• Related Prescribing Note |
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