Monograph Details
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Infections & Infestations
> Bacterial infections
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Gentamicin Inj |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Aminoglycoside. |
| Generic Name |
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Gentamicin sulfate 40mg/mL; IM, or IV inj after dilution; contains sulfites. |
| Indications |
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Serious susceptible infections. |
| Children |
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Premature and infants <1 week: 2.5mg/kg every 12 hours. Neonates: 2.5mg/kg every 8 hours. Others: 2–2.5mg/kg every 8 hours. |
| Adults |
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Obesity: Base dose on lean body mass. Usual duration 7–10 days. 1mg/kg IM or IV every 8 hours; max 5mg/kg/day. For alternative dosing regimens (eg, extended intervals) see literature. |
| Precautions |
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Monitor for nephro- and neurotoxicity; avoid peak serum levels >12micrograms/mL (when dosed at conventional intervals) and trough levels >2micrograms/mL. Renal impairment: reduce dose, see literature; maintain adequate hydration. Prolonged use or excessive doses. Asthma. Neuromuscular disorders. Elderly. Pregnancy (Cat.D): not recommended. |
| Interactions |
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Avoid concomitant furosemide, ethacrynic acid, other nephro/neurotoxic drugs including cephalosporins. May potentiate neuromuscular blockade. |
| Adverse Reactions |
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Nephro- or neurotoxicity, respiratory depression, lethargy, confusion, depression, visual disturbances, elevated liver enzymes, blood dyscrasias. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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