Monograph Details
|
|
Infections & Infestations
> Bacterial infections
|
|
GANTRISIN PEDIATRIC |
| Manufacturer |
|
Roche Laboratories |
| Legal Classification |
|
Rx
|
| Pharmacological Class |
|
Sulfonamide. |
| Generic Name |
|
Sulfisoxazole (as acetyl) 500mg/5mL; susp; raspberry flavor; contains alcohol 0.3%. |
| Indications |
|
Susceptible infections. |
| Children |
|
<2 months: only as an adjunct in congenital toxoplasmosis. ≥2 months: initially ½ of 24-hour dose. Maintenance: 150mg/kg per day divided into 4–6 doses; max 6g/day. |
| Adults |
|
Not recommended. |
| Contraindications |
|
3rd trimester pregnancy. Infants. Nursing mothers of ill, stressed, G6PD-deficient, premature, or hyperbilirubinemic infants. |
| Precautions |
|
Not for group A β-hemolytic strep. Discontinue if rash occurs. Hepatic or renal dysfunction. Allergy. Asthma. G6PD deficiency. Diabetes. Maintain adequate hydration. Monitor CBC, urine, and renal function. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
|
Potentiates oral anticoagulants (monitor PT), sulfonylureas, methotrexate, thiopental, phenytoin. Antagonized by PABA. May form insoluble precipitate with methenamine metabolites. |
| Adverse Reactions |
|
GI upset, rash (may be serious, e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis), photosensitivity, depression, convulsions, ataxia, lupus-like syndrome, peripheral neuritis, blood dyscrasias, hemolysis, megaloblastic anemia, hepatotoxicity, nephrotoxicity with crystalluria, pancreatitis, pseudomembranous colitis. |
| How Supplied |
|
Susp—pt |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
