Monograph Details
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Infections & Infestations
> Bacterial infections
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FURADANTIN |
| Manufacturer |
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Sciele Pharma, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Antibiotic. |
| Generic Name |
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Nitrofurantoin 25mg/5mL; susp. |
| Indications |
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Susceptible UTIs. |
| Children |
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Take with food. <1month: contraindicated. ≥1month: 5–7mg/kg per day in 4 divided doses. Suppressive therapy: 1mg/kg per day in 1–2 divided doses may suffice. |
| Adults |
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Take with food. 50–100mg 4 times daily. Suppressive therapy: 50–100mg once daily at bedtime may suffice. |
| Contraindications |
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Renal impairment (CrCl <60mL/min, anuria, oliguria, or significantly elevated serum creatinine). Neonates. Labor & delivery. Pregnancy at term. |
| Precautions |
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Renal insufficiency. G6PD or Vit. B deficiency. Anemia. Diabetes. Electrolyte imbalance. Asthma. Debilitated. Discontinue if pulmonary or hepatic disorders, hemolysis, or peripheral neuropathy occurs. Monitor renal and pulmonary function in long-term use. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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Avoid magnesium trisilicate. Antagonized by, and increased toxicity with uricosurics (eg, probenecid). May cause false (+) glucose test with Benedict's or Fehling's solution. |
| Adverse Reactions |
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GI upset, dizziness, headache, pulmonary or hematological disorders (esp. in long-term use), peripheral neuropathy; rare: hepatic dysfunction, exfoliative dermatitis, Stevens-Johnson syndrome, optic neuritis, methemoglobinemia. |
| How Supplied |
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Susp—60mL, 470mL |
| Additional Resources |
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• Related Prescribing Note |
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