Monograph Details
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Infections & Infestations
> Bacterial infections
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FORTAZ |
| Manufacturer |
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GlaxoSmithKline Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Cephalosporin. |
| Generic Name |
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Ceftazidime 500mg, 1g, 2g; IM or IV inj; sodium content 2.3mEq/g. |
| Indications |
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Susceptible infections including septicemia, pneumonia, skin and skin structure, bone and joint, gynecologic, intraabdominal, meningitis, urinary tract. |
| Children |
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Neonates: 30mg/kg IV every 12 hours. 1 month–12 years: 30–50mg/kg IV every 8 hours; max 6g/day. Renal impairment: reduce dose. |
| Adults |
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Uncomplicated pneumonia, mild skin or skin structure: 500mg–1g IV or IM every 8 hours. Serious gynecologic, intraabdominal, meningitis, or very severe life-threatening (esp. immunocompromised): 2g IV every 8 hours. Bone and joint: 2g IV every 12 hours. Uncomplicated UTIs: 250mg IV or IM every 12 hours. Complicated UTIs: 500mg IV or IM every 8–12 hours. Renal dysfunction: CrCl 31–50mL/min: 1g every 12 hours; CrCl 16–30mL/min: 1g every 24 hours; CrCl 6–15mL/min: 500mg every 24 hours; CrCl <5mL/min: 500mg every 48 hours. Hemodialysis: 1g loading dose then 1g after dialysis session. Peritoneal dialysis: 1g loading dose then 500mg every 24 hours. |
| Precautions |
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Penicillin or other allergy. Renal impairment. Monitor prothrombin time in renal or hepatic dysfunction, poor nutritional states, or long-term use. GI disease (esp. colitis). Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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May potentiate nephrotoxicity of aminoglycosides or diuretics. Antagonized by chloramphenicol. False (+) glucose test with Clinitest, Benedict's, or Fehling's soln. |
| Adverse Reactions |
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Hypersensitivity reactions (eg, rash, pruritus, fever), local reactions, GI upset, elevated liver enzymes. |
| How Supplied |
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Vials—10 |
| Additional Resources |
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• Related Prescribing Note |
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