Monograph Details
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Infections & Infestations
> Bacterial infections
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FLOXIN |
| Manufacturer |
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Ortho-McNeil Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Quinolone. |
| Generic Name |
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Ofloxacin 200mg, 300mg, 400mg; tabs. |
| Indications |
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Susceptible infections including acute bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, acute pelvic inflammatory disease (PID), cervical, acute uncomplicated gonorrhea, uncomplicated skin and skin structure, UTIs, prostatitis. |
| Children |
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<18yrs: not recommended. |
| Adults |
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≥18yrs: Take on empty stomach with full glass water. Bronchitis, pneumonia: 400mg every 12 hours for 10 days. Urethritis, cervicitis: 300mg every 12 hours for 7 days. Gonorrhea: 400mg once as a single dose. PID: 400mg every 12 hours for 10–14 days. Uncomplicated cystitis due to E. coli or K. pneumoniae: 200mg every 12 hrs for 3 days. Other uncomplicated UTIs: 200mg every 12 hrs for 7 days. Complicated UTIs: 200mg every 12 hrs for 10 days. Prostatitis due to E. coli: 300mg every 12 hours for 6 weeks. Severe hepatic impairment: max 400mg/day. Renal impairment: CrCl 20–50mL/min: give normal dose (loading dose) and increase dosing interval to 24 hours. CrCl <20mL/min: give normal dose once (loading dose) then ½ normal dose and increase dosing interval to 24 hours. |
| Precautions |
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Maintain adequate hydration. CNS disorders (e.g., cerebral arteriosclerosis, epilepsy) that increase seizure risk. Avoid excessive sun or UV light. Monitor blood, renal, and hepatic function in prolonged use. Renal or severe hepatic impairment. Discontinue if CNS effects, photosensitization, or tendon pain, inflammation or rupture occurs. Pregnancy (Cat.C), nursing mothers: not recommended. |
| Interactions |
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Avoid minerals, antacids, sucralfate, didanosine (separate dosing by 2 hrs). Increased risk of seizures with NSAIDs. May potentiate theophylline, warfarin. May potentiate insulin, oral hypoglycemics (discontinue ofloxacin if hypoglycemia occurs). Monitor drugs metabolized by CYP450. |
| Adverse Reactions |
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CNS stimulation (e.g., convulsions, nervousness, anxiety), phototoxicity, GI upset, insomnia, headache, dizziness, tendinitis/rupture. |
| How Supplied |
Tabs 200mg, 300mg—50
Tabs 400mg—100 |
| Additional Resources |
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• Related Prescribing Note |
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