Monograph Details
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Infections & Infestations
> Bacterial infections
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FLAGYL I.V. INJECTION |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Nitroimidazole. |
| Generic Name |
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Metronidazole 500mg/vial; 500mg/100mL. |
| Also |
• FLAGYL
• FLAGYL 375
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| Indications |
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Susceptible anaerobic infections. Surgical prophylaxis. |
| Children |
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Not recommended. |
| Adults |
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Infuse over 1 hour. Anaerobic infections: 15mg/kg (loading dose), then 7.5mg/kg every 6 hours; max 4g/day. Prophylaxis: see literature. |
| Contraindications |
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Pregnancy (1st trimester for trichomoniasis). |
| Precautions |
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CNS disease. Discontinue if neurological symptoms occur. Severe hepatic disease: reduce dose. Candidiasis. History of blood dyscrasias. Monitor leukocytes before and after therapy. Elderly: monitor serum levels. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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Avoid alcohol during and for 3 days after use. Do not give within 2 weeks of disulfiram (possible psychotic reactions). May potentiate oral anticoagulants, phenytoin, lithium. Antagonized by phenobarbital, phenytoin, other hepatic enzyme inducers. May impair phenytoin clearance. Potentiated by cimetidine, other hepatic enzyme inhibitors. Interferes with serum chemistry tests. |
| Adverse Reactions |
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Seizures, peripheral neuropathy, GI upset, anorexia, constipation, headache, metallic taste, ECT changes, dysuria. |
| How Supplied |
Tabs—50, 100
Caps 375mg—50
I.V. vials—10
I.V. ready-to-use—24 |
| Additional Resources |
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• Related Prescribing Note |
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