Monograph Details
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Infections & Infestations
> Bacterial infections
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FLAGYL |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Nitroimidazole. |
| Generic Name |
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Metronidazole 250mg, 500mg; scored tabs. |
| Also |
• FLAGYL 375
• FLAGYL I.V. INJECTION
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| Indications |
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Susceptible anaerobic infections, including intraabdominal, skin and skin structures, gynecologic, bacterial septicemia, bone and joint, CNS, lower respiratory tract, endocarditis. |
| Children |
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Not recommended. |
| Adults |
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Parenteral form usually used first. 7.5mg/kg every 6 hours for 7–10 days; max 4g/day. |
| Contraindications |
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Pregnancy (1st trimester for trichomoniasis). |
| Precautions |
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CNS disease. Discontinue if neurological symptoms occur. Severe hepatic disease: reduce dose. Candidiasis. History of blood dyscrasias. Monitor leukocytes before and after therapy. Elderly: monitor serum levels. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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Avoid alcohol during and for 3 days after use. Do not give within 2 weeks of disulfiram (possible psychotic reactions). May potentiate oral anticoagulants, phenytoin, lithium. Antagonized by phenobarbital, phenytoin, other hepatic enzyme inducers. May impair phenytoin clearance. Potentiated by cimetidine, other hepatic enzyme inhibitors. Interferes with serum chemistry tests. |
| Adverse Reactions |
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Seizures, peripheral neuropathy, GI upset, anorexia, constipation, headache, metallic taste, ECT changes, dysuria. |
| How Supplied |
Tabs—50, 100
Caps 375mg—50
I.V. vials—10
I.V. ready-to-use—24 |
| Additional Resources |
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• Related Prescribing Note |
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