Monograph Details
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Infections & Infestations
> Bacterial infections
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ERYC |
| Manufacturer |
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Warner Chilcott Laboratories |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Macrolide. |
| Generic Name |
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Erythromycin (as base) 250mg; e-c pellets in caps. |
| Indications |
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Susceptible infections including upper and lower respiratory, skin and soft tissue, genitourinary, Legionnaires' disease, pertussis, listeriosis. |
| Children |
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Mild-to-moderate infections: 30–50mg/kg/day in divided doses 1 hour before meals; may double dose in severe infections; max 100mg/kg/day. |
| Adults |
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250mg every 6 hours 1 hour before meals; max 4g daily. Legionnaires: 1–4g/day in divided doses. |
| Contraindications |
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Concomitant cisapride, pimozide. |
| Precautions |
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Hepatic dysfunction. Myasthenia gravis. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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See Contraindications. May potentiate or be potentiated by drugs metabolized by CYP450 (e.g., carbamazepine, cyclosporine, tacrolimus, hexobarbital, phenytoin, alfentanil, disopyramide, bromocriptine, valproate). May potentiate warfarin, triazolam, midazolam, methylprednisolone, digoxin, theophylline, ergotamine. Avoid use with statins (rhabdomyolysis). |
| Adverse Reactions |
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GI upset, abdominal pain, anorexia, hepatic dysfunction, rash. |
| How Supplied |
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Caps—100 |
| Additional Resources |
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• Related Prescribing Note |
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