Monograph Details
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Infections & Infestations
> Bacterial infections
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DYNACIN |
| Manufacturer |
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Medicis Pharmaceuticals Corp |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Tetracycline. |
| Generic Name |
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Minocycline (as HCl) 50mg, 75mg, 100mg; tabs. |
| Indications |
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Susceptible respiratory, genitourinary, skin and soft tissue, ear/nose/throat infections. |
| Children |
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Take on empty stomach with fluids. <8 years: not recommended. >8 years: 4mg/kg once then 2mg/kg (max 100mg) every 12 hours. |
| Adults |
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Take on empty stomach with fluids. 200mg once then 100mg every 12 hours; or 100–200mg once then 50mg four times daily. Syphilis: treat for 10–15 days. Meningococcal carrier state: 100mg every 12 hours for 5 days. Mycobacterium marinum infection: 100mg every 12 hours for 6–8 weeks has been used. Uncomplicated urethral, endocervical, or rectal infection w. C.trachomatis or U. urealyticum: 100mg every 12 hours for at least 7 days. For men: Uncomplicated gonococcal infection (not urethritis or anorectal): 200mg once then 100mg every 12 hours for at least 4 days; urethritis: 100mg every 12 hours for 5 days. |
| Precautions |
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Renal or hepatic impairment. Monitor blood, renal and hepatic function in long-term use. Pregnancy (Cat.D), nursing mothers: not recommended. |
| Interactions |
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Antacids, iron, calcium, magnesium, urinary alkalinizers reduce absorption. Avoid penicillins, methoxyflurane. Monitor PT with anticoagulants. May antagonize oral contraceptives. |
| Adverse Reactions |
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Dizziness, GI upset, rash, pseudotumor cerebri, blood dyscrasias, increased BUN, interstitial nephritis, hepatotoxicity, tinnitus, tooth discoloration; rare: photosensitivity. |
| How Supplied |
Tabs 50mg, 75mg—100, 1000
100mg—50, 1000 |
| Additional Resources |
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• Related Prescribing Note |
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