Monograph Details
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Infections & Infestations
> Bacterial infections
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CLAFORAN |
| Manufacturer |
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Abbott Laboratories |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Cephalosporin. |
| Generic Name |
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Cefotaxime sodium 500mg, 1g, 2g, 10g; IM or IV inj; sodium content 2.2mEq/g. |
| Indications |
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Susceptible bacteremia, septicemia, lower respiratory and genitourinary tracts, skin and skin structure, bone and joint, gynecologic, CNS (e.g., meningitis), intraabdominal infections. Surgical prophylaxis. |
| Children |
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Neonates up to 1 week of age: 50mg/kg IV every 12 hours. 1–4 weeks of age: 50mg/kg IV every 8 hours. Over 1 month of age (<50kg): 50–180mg/kg in 4–6 equally divided doses. ≥50kg: as adult; max 12g/day. |
| Adults |
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Uncomplicated infections: 1g every 12 hours. Moderate to severe: 1–2g every 8 hours. Gonorrhea: 1 dose of 1g IM. Infections commonly needing a higher dosage (e.g., septicemia): 2g IV every 6–8 hours. Life-threatening: 2g IV every 4 hours. Prophylaxis: see literature. CrCl <20mL/min/1.73m2: consider reducing dose by one-half. |
| Precautions |
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Penicillin or other allergy. Severe renal impairment, reduce dose. GI disease (esp. colitis). Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Increased nephrotoxicity with concomitant aminoglycosides. Potentiated by probenecid. |
| Adverse Reactions |
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Local or hypersensitivity reactions, diarrhea; blood dyscrasias, elevated liver enzymes (rare). |
| How Supplied |
Vials (500mg)—10
(1g, 2g)—10, 25, 50
10g—1 |
| Additional Resources |
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• Related Prescribing Note |
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