Monograph Details
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Infections & Infestations
> Bacterial infections
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CIPRO XR |
| Manufacturer |
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Bayer Corp, Pharmaceutical Div. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Quinolone. |
| Generic Name |
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Ciprofloxacin (as HCl and betaine) 500mg, 1000mg; ext-rel tabs. |
| Also |
• CIPRO
• CIPRO IV CONCENTRATE
• CIPRO IV PREMIXED
• CIPRO ORAL SUSPENSION
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| Indications |
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Susceptible infections including UTIs, acute uncomplicated pyelonephritis. |
| Children |
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<18yrs: not recommended. |
| Adults |
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Swallow whole. ≥18yrs: Uncomplicated UTIs: 500mg once daily for 3 days. Complicated UTIs, acute uncomplicated pyelonephritis: 1000mg once daily for 7–14 days; renal impairment (CrCl <30mL/min): 500mg once daily for 7–14 days. Coincide dose for end of dialysis. |
| Contraindications |
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Concomitant tizanidine. |
| Precautions |
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XR not interchangeable with other forms. Renal (except XR tabs for uncomplicated UTIs) or hepatic dysfunction: reduce dose. Increased risk of tendinitis or tendon rupture esp. in patients >60yrs, or those with kidney, heart or lung transplants. Discontinue if tendon pain, inflammation, or rupture occurs; if rash, phototoxicity, or other sign of hypersensitivity occurs; or if CNS disorders or neuropathy occurs. Conditions that increase seizure risk. History of prolonged QT interval. Hypokalemia. History of joint-related disorders (esp. children). Maintain adequate hydration, avoid alkaline urine to avoid crystalluria. Avoid excessive sun and UV light. May mask symptoms of syphilis; test for syphilis before treating gonorrhea, then follow-up after 3 months. Monitor blood, renal, hepatic function in prolonged use. Elderly. Pregnancy (Cat.C), nursing mothers: usually not recommended. |
| Interactions |
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Avoid theophylline (increases theophylline levels; may potentiate other CYP1A2 substrates), urinary alkalinizers; oral forms with antacids, calcium, iron, zinc, sucralfate, buffered forms of didanosine, other highly buffered drugs (may give ciprofloxacin 2 hrs before or 6 hrs after); high ciprofloxacin doses with NSAIDs (increases seizure risk). Potentiates caffeine. Potentiated by probenecid. Severe hypoglycemia with glyburide (rare). Increased serum creatinine with cyclosporine. Monitor methotrexate, oral anticoagulants (potentiation), phenytoin (variable effects). Increased risk of tendinitis and tendon rupture with corticosteroids. Caution with other drugs that lower seizure threshold. Increased risk of QT prolongation with Class IA or III antiarrhythmics. Reduced absorption with omeprazole (XR). |
| Adverse Reactions |
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GI upset, headache, CNS disturbances (eg, convulsions, dizziness, nervousness, insomnia, nightmares, paranoia), rash, eosinophilia, elevated liver enzymes, photosensitivity, Stevens-Johnson syndrome, myalgia, tendinitis/rupture, joint-related disorders (children), local reactions (inj); rare: increased intracranial pressure, toxic psychosis; peripheral neuropathy. |
| Extra Text |
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Note: See MMWR Vol 50, No.42 (Oct. 26, 2001) for more information on anthrax. |
| How Supplied |
Tabs 250mg, 500mg—100
750mg—50
Oral Susp—100mL
Inj Conc (20mL, 40mL)—1
Infusion (100mL, 200mL)—1
XR Tabs—50, 100 |
| Additional Resources |
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• Related Prescribing Note |
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