Monograph Details
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Infections & Infestations
> Bacterial infections
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CEFTIN |
| Manufacturer |
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GlaxoSmithKline Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Cephalosporin. |
| Generic Name |
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Cefuroxime (as axetil) 250mg, 500mg; tabs. |
| Also |
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• CEFTIN ORAL SUSPENSION
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| Indications |
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Susceptible mild to moderate infections including pharyngitis/tonsillitis, acute maxillary sinusitis, bronchitis, acute otitis media; uncomplicated skin and skin structure, UTIs, gonorrhea; early Lyme disease. |
| Children |
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Swallow tab whole, or use susp. Otitis media, sinusitis: 250mg twice daily for 10 days. |
| Adults |
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≥13 years: Pharyngitis/tonsillitis, sinusitis: 250mg twice daily for 10 days. Acute bacterial exacerbations of chronic bronchitis, skin and skin structure infections: 250–500mg twice daily for 10 days. Secondary bacterial infections of acute bronchitis: 250–500mg twice daily for 5–10 days. UTIs: 250mg twice daily for 7–10 days. Gonorrhea: 1g as a single dose. Lyme disease: 500mg twice daily for 20 days. |
| Precautions |
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Tabs and susp not bioequivalent; do not interchange on a mg/mg basis. Penicillin or other allergy. History of colitis; discontinue if colitis occurs and treat. Renal impairment. Monitor prothrombin time in renal or hepatic dysfunction, stabilized on anticoagulant, poor nutritional state, or long-term use. Labor & delivery. Pregnancy (Cat.B). Nursing mothers: consider discontinuing nursing during treatment. |
| Interactions |
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May cause false (+) Fehling's or Benedict's soln, Clinitest, or Coomb's test. Antacids, others that decrease gastric acidity may inhibit absorption. Potentiated by probenecid. Caution with potent diuretics, other nephrotoxic drugs. |
| Adverse Reactions |
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GI disturbances, transient increase of AST, ALT, LDH, eosinophilia, bitter taste; convulsions (overdose). |
| How Supplied |
Tabs—20, 60
Susp 125mg/5mL—100mL
Susp 250mg/5mL—50mL, 100mL |
| Additional Resources |
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• Related Prescribing Note |
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