Monograph Details
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Infections & Infestations
> Bacterial infections
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Cefotetan |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Cephalosporin. |
| Generic Name |
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Cefotetan disodium 1g, 2g; IM or IV inj; sodium content 3.5mEq/g. |
| Indications |
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Susceptible lower respiratory tract or urinary tract, skin and skin structure, bone and joint, gynecologic, intraabdominal infections. Surgical prophylaxis. |
| Children |
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Not recommended. |
| Adults |
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Treatment: give for at least 5–10 days. UTI: 500mg IV or IM every 12 hours or 1–2g IV or IM every 12–24 hours. Mild to moderate skin and skin structures: 2g IV every 24 hours or 1g IV or IM every 12 hours. Severe skin and skin structure: 2g IV every 12 hours. Other sites: 1–2g IV or IM every 12 hours. Severe: 2g IV every 12 hours. Life threatening: 3g IV every 12 hours; max 6g/day. Prophylaxis: 1–2g IV once 30–60 minutes before surgery. CrCl <30mL/min: reduce dose, see literature. |
| Contraindications |
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Previous cephalosporin-associated hemolytic anemia. |
| Precautions |
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Penicillin or other allergy. Renal impairment. Renal or hepatic dysfunction, poor nutritional state, cancer patients, elderly or debilitated: monitor prothrombin time. Monitor for hemolytic anemia in prolonged use. GI disease (esp. colitis). Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Avoid alcohol for 72 hours after dosing. Avoid other nephrotoxic drugs. Potentiated by probenecid. May cause false (+) Clinitest, Benedict's or Fehling's soln. May interfere with creatinine tests. |
| Adverse Reactions |
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GI upset, rash, pruritus, local reactions, anaphylaxis, blood dyscrasias, elevated liver enzymes. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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