Monograph Details
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Infections & Infestations
> Bacterial infections
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BIAXIN ORAL SUSPENSION |
| Manufacturer |
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Abbott Laboratories |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Macrolide. |
| Generic Name |
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Clarithromycin 125mg/5mL, 250mg/5mL; granules for oral susp; fruit-punch flavor. |
| Also |
• BIAXIN
• BIAXIN XL
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| Indications |
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Mild to moderate susceptible pharyngitis/tonsillitis, acute bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, acute maxillary sinusitis, acute otitis media, uncomplicated skin and skin structure infections. Disseminated M. intracellulare. Treatment (with other antimycobacterials) and prophylaxis of disseminated Mycobacterium avium complex (MAC). |
| Children |
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<6 months: not recommended. Otitis media, pharyngitis/tonsillitis, pneumonia, sinusitis, skin and skin structures: 7.5mg/kg every 12 hours for 10 days. MAC (see literature): 7.5mg/kg every 12 hours; max 500mg twice daily, continue indefinitely if improvement occurs. CrCl <30mL/min: ½ dose or double dosing interval. |
| Adults |
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Pharyngitis/tonsillitis: 250mg every 12 hours for 10 days. Bronchitis: 250mg–500mg every 12 hours for 7–14 days. CAP, skin and skin structures: 250mg every 12 hours for 7–14 days. Sinusitis: 500mg every 12 hours for 14 days. MAC: 500mg every 12 hours continue indefinitely if improvement occurs. CrCl <30mL/min: ½ dose or double dosing interval. |
| Contraindications |
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Concomitant cisapride, pimozide. |
| Precautions |
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Severe renal impairment. Pregnancy (Cat.C): usually not recommended. Nursing mothers. |
| Interactions |
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See Contraindications. May potentiate theophylline, carbamazepine, omeprazole, phenytoin, digoxin, warfarin, ergot alkaloids, triazolam, cyclosporine, hexobarbital, tacrolimus, alfentanil, disopyramide, bromocriptine, valproate, rifabutin, statins; monitor these and others metabolized by CYP450. May affect zidovudine levels. With ritonavir in renal impairment: reduce clarithromycin dose (see literature). |
| Adverse Reactions |
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GI upset, abnormal taste, headache, rash, increased BUN. |
| How Supplied |
XL tabs, tabs—60
Biaxin XL-Pac (14 x 500mg XL tabs)—4
Susp—50mL, 100mL |
| Additional Resources |
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• Related Prescribing Note |
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