Monograph Details
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Infections & Infestations
> Bacterial infections
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BACTRIM DS |
| Manufacturer |
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AR Scientific |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Sulfonamide + folic acid inhibitor. |
| Generic Name |
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Sulfamethoxazole 800mg, trimethoprim 160mg; scored tabs. |
| Also |
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• BACTRIM
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| Indications |
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Susceptible infections including UTIs (not for initial uncomplicated episodes), shigellosis, prophylaxis and treatment of Pneumocystis carinii pneumonia (PCP), travelers' diarrhea or acute exacerbations of chronic bronchitis in adults, acute otitis media in children. |
| Children |
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<2months: not recommended. ≥2months: 8mg/kg per day trimethoprim (40mg/kg per day of sulfamethoxazole) in 2 divided doses at 12 hour intervals for 5 days (shigellosis) or 10 days (otitis media, UTIs). PCP treatment: as adult; PCP prophylaxis or renal impairment: see literature. |
| Adults |
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1 DS tab or 2 regular tabs every 12 hours for 5 days (shigellosis, travelers' diarrhea), or 10–14 days (UTIs), or 14 days (bronchitis). PCP treatment: 15–20mg/kg per day of trimethoprim (75–100mg/kg per day of sulfamethoxazole) in 4 divided doses at 6 hour intervals for 14–21 days; PCP prophylaxis: one DS tab daily. Renal impairment (CrCl 15–30mL/min): reduce dose by ½; CrCl <15mL/min: not recommended. |
| Contraindications |
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Megaloblastic anemia due to folate deficiency. 3rd trimester pregnancy (Cat.C). Infants. Nursing mothers of ill, stressed, G6PD-deficient, premature, or hyperbilirubinemic infants. |
| Precautions |
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Not for group A β-hemolytic strep. Avoid prolonged administration. Monitor blood, urine, and renal function. Hepatic or renal dysfunction. AIDS (increased risk of toxicities). Folate or G6PD deficiency. Allergy. Maintain adequate hydration. Discontinue if rash occurs. Elderly. |
| Interactions |
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May potentiate oral anticoagulants, hypoglycemics, phenytoin, methotrexate. May be potentiated by indomethacin. May form insoluble precipitate with methenamine metabolites. May increase risk of thrombocytopenia with diuretics (esp. thiazides). |
| Adverse Reactions |
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GI upset, allergic skin reactions, blood dyscrasias (eg, megaloblastic anemia), hemolysis, hepatic or renal toxicity, crystalliuria, pancreatitis, photosensitivity, drug fever, rash (may be serious, eg, Stevens-Johnson syndrome, toxic epidermal necrolysis), lupus-like syndrome, peripheral neuritis, depression, convulsions, ataxia. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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