Monograph Details
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Infections & Infestations
> Bacterial infections
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AUGMENTIN XR |
| Manufacturer |
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GlaxoSmithKline Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Broad-spectrum penicillin + β-lactamase inhibitor. |
| Generic Name |
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Amoxicillin 1000mg, clavulanic acid (as potassium) 62.5mg; scored ext-rel tabs. |
| Also |
• AUGMENTIN 125 CHEWABLE
• AUGMENTIN 125 SUSP
• AUGMENTIN 200 CHEWABLE
• AUGMENTIN 200 SUSP
• AUGMENTIN 250
• AUGMENTIN 250 CHEWABLE
• AUGMENTIN 250 SUSP
• AUGMENTIN 400 CHEWABLE
• AUGMENTIN 400 SUSP
• AUGMENTIN 500
• AUGMENTIN 875
• AUGMENTIN ES-600 SUSP
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| Indications |
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Susceptible infections including community-acquired pneumonia and acute bacterial sinusitis (see literature). |
| Children |
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<16yrs: not recommended. |
| Adults |
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Take with meals. May split scored tabs; do not reduce dose. Two Augmentin 500mg tabs are not equivalent to one XR tab. ≥16yrs: 2 tabs every 12 hrs. Sinusitis: treat for 10 days. CAP: treat for 7–10 days. |
| Contraindications |
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History of Augmentin-associated cholestatic jaundice/hepatic dysfunction. XR: Severe renal impairment (CrCl <30mL/min) or hemodialysis. |
| Precautions |
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Cephalosporin, imipenem, or other allergy: not recommended. Monitor blood, renal, and hepatic function in long-term use. Hepatic dysfunction. Mononucleosis. Elderly (consider monitoring renal function). Labor & delivery. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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May cause false (+) glucose test with Clinitest, Benedict's or Fehling's soln. Probenecid potentiates amoxicillin. |
| Adverse Reactions |
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Diarrhea, nausea, abdominal pain, rash, urticaria, vomiting, vaginitis, anaphylaxis. |
| How Supplied |
XR tabs—28, 40
Tabs 250mg—30
Tabs 500mg, 875mg—20
Susp 125mg/5mL, 250mg/5mL—75mL, 100mL, 150mL
Susp 200mg/5mL, 400mg/5mL—50mL, 75mL, 100mL
Chew tabs 125mg, 250mg—30
Chew tabs 200mg, 400mg—20
Susp ES-600 600mg/5mL—50mL, 75mL, 100mL, 125mL, 150mL, 200mL |
| Additional Resources |
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• Related Prescribing Note |
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