Monograph Details
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Infections & Infestations
> Bacterial infections
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AUGMENTIN 250 SUSP |
| Manufacturer |
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GlaxoSmithKline Pharmaceuticals |
| Legal Classification |
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Rx
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| Generic Name |
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Amoxicillin 250mg, clavulanic acid (as potassium) 62.5mg; per 5mL; orange flavor. |
| Also |
• AUGMENTIN 125 CHEWABLE
• AUGMENTIN 125 SUSP
• AUGMENTIN 200 CHEWABLE
• AUGMENTIN 200 SUSP
• AUGMENTIN 250
• AUGMENTIN 250 CHEWABLE
• AUGMENTIN 400 CHEWABLE
• AUGMENTIN 400 SUSP
• AUGMENTIN 500
• AUGMENTIN 875
• AUGMENTIN ES-600 SUSP
• AUGMENTIN XR
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| Indications |
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Susceptible infections including sinusitis due to β-lactamase producing organisms, otitis media, lower respiratory or skin and skin structure infections, UTIs. |
| Children |
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Take with meals. Base dose on amoxicillin component. <12 weeks: 30mg/kg/day in 2 divided doses every 12 hrs (use 125mg/5mL). ≥12 weeks: Twice-daily regimen: use 200mg/5mL or 400mg/5mL. Three times daily regimen: use 125mg/5mL or 250mg/5mL. Less severe infections: 25mg/kg/day in 2 divided doses every 12 hrs or 20mg/kg/day in 3 divided doses every 8 hrs. Others: 45mg/kg/day in 2 divided doses every 12 hrs or 40mg/kg/day in 3 divided doses every 8 hrs. ≥40kg: see Adult dose. |
| Adults |
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Take with meals. Base dose on amoxicillin component. Due to clavulanic acid component, two 250mg tabs are not equivalent to one 500mg tab. May use 125mg/5mL or 250mg/5mL susp in place of 500mg tab; or 200mg/5mL or 400mg/5mL susp in place of 875mg tab. Severe infections or respiratory tract infections: 875mg every 12 hrs or 500mg every 8 hrs. Others: 500mg every 12 hrs or 250mg every 8 hrs. Renal impairment: CrCl<30mL/min: do not use 875mg tabs. CrCl: 10–30mL/min: 250–500mg every 12 hrs. CrCl<10mL/min: 250mg–500mg every 24 hrs; hemodialysis: give additional doses during and after dialysis. |
| Contraindications |
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History of Augmentin-associated cholestatic jaundice/hepatic dysfunction. XR: Severe renal impairment (CrCl <30mL/min) or hemodialysis. |
| Precautions |
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Cephalosporin, imipenem, or other allergy: not recommended. Monitor blood, renal, and hepatic function in long-term use. Hepatic dysfunction. Mononucleosis. Elderly (consider monitoring renal function). Labor & delivery. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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May cause false (+) glucose test with Clinitest, Benedict's or Fehling's soln. Probenecid potentiates amoxicillin. |
| Adverse Reactions |
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Diarrhea, nausea, abdominal pain, rash, urticaria, vomiting, vaginitis, anaphylaxis. |
| How Supplied |
XR tabs—28, 40
Tabs 250mg—30
Tabs 500mg, 875mg—20
Susp 125mg/5mL, 250mg/5mL—75mL, 100mL, 150mL
Susp 200mg/5mL, 400mg/5mL—50mL, 75mL, 100mL
Chew tabs 125mg, 250mg—30
Chew tabs 200mg, 400mg—20
Susp ES-600 600mg/5mL—50mL, 75mL, 100mL, 125mL, 150mL, 200mL |
| Additional Resources |
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• Related Prescribing Note |
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