Monograph Details
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Infections & Infestations
> Bacterial infections
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AMOXIL |
| Manufacturer |
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GlaxoSmithKline Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Broad-spectrum penicillin. |
| Generic Name |
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Amoxicillin (as trihydrate) 500mg; caps. |
| Indications |
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Susceptible infections including ear/nose/throat (ENT), lower respiratory tract, skin and skin structure, genitourinary tract, acute uncomplicated gonorrhea. |
| Children |
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For treating acute otitis media: The AAP recommends 80–90mg/kg per day in divided doses (note: this is not an FDA-approved dose). Do not exceed recommended adult dose. >40kg: dose as adults. Neonates and infants ≤3months: max 30mg/kg per day in divided doses every 12hrs. >3months: Mild to moderate ENT, skin, or genitourinary: 25mg/kg per day in divided doses every 12hrs or, 20mg/kg per day in divided doses every 8hrs. Lower respiratory or severe ENT, skin, or genitourinary: 45mg/kg per day in divided doses every 12hrs or, 40mg/kg per day in divided doses every 8hrs. Gonorrhea: ≤2yrs: not recommended; >2yrs: 50mg/kg with 25mg/kg probenecid once. Renal dysfunction: not recommended. |
| Adults |
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Mild to moderate ENT, skin, or genitourinary: 500mg every 12hrs or 250mg every 8hrs. Lower respiratory or severe ENT, skin, or genitourinary: 875mg every 12hrs or 500mg every 8hrs. Gonorrhea: 3g once. Severe renal impairment (CrCl <30mL/min): 875mg tabs not recommended; CrCl 10–30mL/min: 250–500mg every 12hrs; CrCl <10mL/min: 250–500mg every 24hrs (give additional doses during and after hemodialysis). |
| Precautions |
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Cephalosporin, imipenem, other allergy or mononucleosis: not recommended. Monitor blood, renal, and hepatic function in long-term use. Labor & delivery. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Potentiated by probenecid. May cause false (+) glucose test with Clinitest, Benedict's or Fehling's soln. |
| Adverse Reactions |
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GI upset, hypersensitivity reactions (eg, urticaria, rash, Stevens-Johnson syndrome, anaphylaxis), hyperactivity, blood dyscrasias. |
| How Supplied |
Caps—500
Susp 250mg/5mL—100mL, 150mL
Susp 400mg/5mL—100mL
Drops 50mg/mL—30mL |
| Additional Resources |
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• Related Prescribing Note |
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