Monograph Details
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Immune System
> Immunomodulators
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AVONEX |
| Manufacturer |
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Biogen Idec, Inc. |
| Legal Classification |
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Rx
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| Generic Name |
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Interferon beta-1a 30micrograms per prefilled syringe (albumin-free liq for IM inj) or per vial (pwd for IM inj after reconstitution (preservative-free); contains albumin (human). |
| Indications |
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Treatment of relapsing forms of multiple sclerosis to slow the accumulation of physical disability and decrease the frequency of clinical exacerbations in patients with first clinical episode and MRI consistent with MS. |
| Children |
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<18yrs: not recommended. |
| Adults |
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≥18yrs: 30micrograms IM once weekly. |
| Precautions |
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Depression. Suicidal ideation. Seizure disorders. Myelosuppression. Cardiac disease. Monitor hemoglobin, CBC, differential, platelets, blood chemistries, liver and thyroid function, and for autoimmune disorders. Pregnancy (Cat.C), may be abortifacient; consider discontinuing drug. Nursing mothers: not recommended. |
| Interactions |
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Avoid alcohol. Monitor with myelosuppressants or hepatotoxic drugs. |
| Adverse Reactions |
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Flu-like symptoms, asthenia, anemia, headache, GI upset, depression, blood dyscrasias, seizures; rare: hepatic injury. |
| Extra Text |
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Note: Register pregnant patients exposed to Avonex by calling (800) 456-2255. |
| How Supplied |
Prefilled syringes (0.5mL) dose pack—1 (4 syringes, supplies)
Single-use vial dose pack—1 (4 vials, diluent, supplies) |
| Additional Resources |
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• Related Prescribing Note |
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